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Converting to Opana

Converting from other short-acting oral opioids to OPANA

* Ratio for conversion of oral opioid dose to approximate OPANA equivalent dose. Select opioid and multiply the dose by the conversion ratio to calculate the approximate oral oxymorphone equivalent.

† It is extremely important to monitor all patients closely when converting from methadone to other opioid agonists. The ratio between methadone and other opioid agonists may vary widely as a function of previous dose exposure. Methadone has a long half-life and tends to accumulate in the plasma.

The conversion ratios and approximate equivalent doses in this conversion table are only to be used for the conversion from current opioid therapy to OPANA.

Conversion steps

  • Step 1: Use the conversion chart to calculate the total daily dose of OPANA
  • Step 2: Administer this calculated total daily dose as equally divided doses every 4-6 hours as needed
  • Step 3: Titrate as needed until adequate pain relief and acceptable side effects have been achieved

Vicodin® to OPANA sample calculation

A healthcare professional with a patient on a total daily dose of Vicodin 40 mg hydrocodone/4,000 mg APAP could do the following calculation:

  1. 40 mg hydrocodone x 0.5 = 20 mg (approximate oxymorphone total daily dose)
  2. Administer as 5 mg OPANA every 4-6 hours as needed
  3. Titrate as needed

Learn about Converting from OPANA to OPANA ER

To convert from OPANA to OPANA ER, please use our new dosage conversion calculator.

Additional Safety Information1

  • Patients must not consume alcoholic beverages, or prescription or nonprescription medications containing alcohol, while on OPANA therapy. The co-ingestion of alcohol with OPANA may result in increased plasma levels and a potentially fatal overdose of oxymorphone
  • OPANA should be administered on an empty stomach, at least 1 hour prior to or 2 hours after eating
  • Elderly patients, patients with mild hepatic impairment and patients with moderate or severe renal impairment should be started at the lowest dose and titrated slowly while carefully monitoring for side effects
  • OPANA, like all opioid analgesics, should be started at 1/3 to 1/2 of the usual dose in patients who are concurrently receiving other CNS depressants
  • Safety and effectiveness of OPANA in pediatric patients below the age of 18 years have not been established

Vicodin® is a registered trademark of Abbott Laboratories.


References

  1. OPANA Full Prescribing Information. Chadds Ford, Pa: Endo Pharmaceuticals; 2006.
  2. OPANA ER Full Prescribing Information. Chadds Ford, Pa: Endo Pharmaceuticals; 2008.