Use our new dosage conversion calculator to find the suggested OPANA^® ER approximate starting dose when converting from other opioids.

The following dosing recommendations should only be considered as suggested approaches to what is actually a series of clinical decisions over time in the management of the pain of each individual patient.

These conversion guidelines are based on conversion ratios listed in the Prescribing Information for OPANA ER.

The suggested starting regimen is only an approximation. Criteria for initial dose selection include, but are not limited to, type and severity of the patient’s pain and age, general condition, and medical status of the patient.

• The conversion ratios and approximate equivalent doses in this conversion table are only to be used for the conversion from current opioid therapy to OPANA ER.
• Sum the total daily dose for the opioid and multiply by the conversion ratio to calculate the oxymorphone total daily dose.
• For patients on a regimen of mixed opioids, calculate the approximate oral oxymorphone dose for each opioid and sum the totals to estimate the total daily oxymorphone dose.
• The dose of OPANA ER can be gradually adjusted, preferably at increments of 10 mg every 12 hours every 3-7 days, until adequate pain relief and acceptable side effects have been achieved (see Individualization of Dose).

* It is extremely important to monitor all patients closely when converting from methadone to other opioid agonists. The ratio between methadone and other opioid agonists may vary widely as a function of previous dose exposure. Methadone has a long half-life and tends to accumulate in the plasma.