Opana® ER does not require dose adjustment for CYP3A4
or 2C9-mediated drug-drug interactions1,*
It is also important to consider pharmacodynamic interactions when prescribing
Opana® ER (see Important Safety Information)
other CNS depressants.
Effect of inhibitors on CYP450-metabolized opioids
Effect of inducers on CYP450-metabolized opioids
*At therapeutically relevant plasma concentrations in in vivo and in vitro studies.